2E4V

Crystal structure of the extracellular region of the group II metabotropic glutamate receptor complexed with DCG-IV

2E4V の概要

• エントリーDOI: 10.2210/pdb2e4v/pdb
• 関連するPDBエントリー: 2E4U 2E4W 2E4X 2E4Y 2E4Z
• 分子名称: Metabotropic glutamate receptor 3, 2-acetamido-2-deoxy-beta-D-glucopyranose, (1R,2R)-3-[(S)-amino(carboxy)methyl]cyclopropane-1,2-dicarboxylic acid, ... (4 entities in total)
• 機能のキーワード: g-protein-coupled receptor, neuron, central nerve system, signaling protein
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P31422
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 127083.31

構造登録者

Muto, T.,Tsuchiya, D.,Morikawa, K.,Jingami, H. (登録日: 2006-12-17, 公開日: 2007-02-27, 最終更新日: 2024-11-06)

主引用文献

Muto, T.,Tsuchiya, D.,Morikawa, K.,Jingami, H.
Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
Proc.Natl.Acad.Sci.Usa, 104:3759-3764, 2007

PubMed Abstract: Metabotropic glutamate receptors play major roles in the activation of excitatory synapses in the central nerve system. We determined the crystal structure of the entire extracellular region of the group II receptor and that of the ligand-binding region of the group III receptor. A comparison among groups I, II, and III provides the structural basis that could account for the discrimination of group-specific agonists. Furthermore, the structure of group II includes the cysteine-rich domain, which is tightly linked to the ligand-binding domain by a disulfide bridge, suggesting a potential role in transmitting a ligand-induced conformational change into the downstream transmembrane region. The structure also reveals the lateral interaction between the two cysteine-rich domains, which could stimulate clustering of the dimeric receptors on the cell surface. We propose a general activation mechanism of the dimeric receptor coupled with both ligand-binding and interprotomer rearrangements.

PubMed: 17360426
DOI: 10.1073/pnas.0611577104

実験手法

X-RAY DIFFRACTION (2.4 Å)