2E2D

Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2

2E2D の概要

• エントリーDOI: 10.2210/pdb2e2d/pdb
• 関連するPDBエントリー: 1BQQ 1BR9 1BUV 830C
• 分子名称: Matrix metallopeptidase 13, Metalloproteinase inhibitor 2, ZINC ION, ... (5 entities in total)
• 機能のキーワード: matrix metalloproteinase-mmp; collagenase; tissue inhibitor of metalloproteinases-timp; complex, flexibility, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space, extracellular matrix (Probable): P45452; Secreted: P16368
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39011.11

構造登録者

Maskos, K.,Lang, R.,Tschesche, H.,Bode, W. (登録日: 2006-11-11, 公開日: 2007-03-13, 最終更新日: 2023-08-23)

• 主引用文献: Maskos, K.,Lang, R.,Tschesche, H.,Bode, W.; Flexibility and Variability of TIMP Binding: X-ray Structure of the Complex Between Collagenase-3/MMP-13 and TIMP-2; J.Mol.Biol., 366:1222-1231, 2007; PubMed: 17196980; DOI: 10.1016/j.jmb.2006.11.072

実験手法

X-RAY DIFFRACTION (2 Å)