2DYN

DYNAMIN (PLECKSTRIN HOMOLOGY DOMAIN) (DYNPH)

2DYN の概要

• エントリーDOI: 10.2210/pdb2dyn/pdb
• 分子名称: DYNAMIN (2 entities in total)
• 機能のキーワード: motor protein, phospholipid binding, protein binding, signal transduction
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q05193
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 28860.78

構造登録者

Timm, D.E. (登録日: 1997-07-21, 公開日: 1997-11-12, 最終更新日: 2024-02-14)

主引用文献

Timm, D.,Salim, K.,Gout, I.,Guruprasad, L.,Waterfield, M.,Blundell, T.
Crystal structure of the pleckstrin homology domain from dynamin.
Nat.Struct.Biol., 1:782-788, 1994

PubMed Abstract: The pleckstrin homology (PH) domain is a conserved module present in many signal transducing and cytoskeletal proteins. Here we report the 2.8 A crystal structure of the PH domain from dynamin. This domain consists of seven beta-strands forming two roughly orthogonal antiparallel beta-sheets terminating with an amphipathic alpha-helix. The structure also reveals a non-covalent dimeric association of the PH domain and a hydrophobic pocket surrounded by a charged rim. The dynamin PH domain structure is discussed in relation to its potential role in mediating interactions between proteins.

PubMed: 7634088
DOI: 10.1038/nsb1194-782

実験手法

X-RAY DIFFRACTION (2.3 Å)