2DW0

Crystal structure of VAP2 from Crotalus atrox venom (Form 2-1 crystal)

Summary for 2DW0

• Entry DOI: 10.2210/pdb2dw0/pdb
• Related: 2DW1 2DW2
• Descriptor: Catrocollastatin, alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)][alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: apoptotic toxin, svmp, metalloproteinase, apoptosis, toxin
• Biological source: Crotalus atrox (western diamondback rattlesnake)
• Cellular location: Secreted: Q90282
• Total number of polymer chains: 2
• Total formula weight: 97039.62

Authors

Takeda, S.,Igarashi, T.,Araki, S. (deposition date: 2006-08-02, release date: 2007-07-10, Last modification date: 2024-10-30)

Primary citation

Igarashi, T.,Araki, S.,Mori, H.,Takeda, S.
Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins
Febs Lett., 581:2416-2422, 2007

PubMed Abstract: Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a metalloproteinase from Crotalus atrox venom, possessing metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the typical domain architecture of a disintegrin and metalloproteinase (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the monomeric class of this family of proteins. The overall structures show good agreement with both monomers of atypical homodimeric VAP1. Comparison of the six catrocollastatin/VAP2B monomer structures and the structures of VAP1 reveals a dynamic, modular architecture that may be important for the functions of ADAM/adamalysin/reprolysin family proteins.

PubMed: 17485084
DOI: 10.1016/j.febslet.2007.04.057

Experimental method

X-RAY DIFFRACTION (2.15 Å)