2DW0

Crystal structure of VAP2 from Crotalus atrox venom (Form 2-1 crystal)

2DW0 の概要

• エントリーDOI: 10.2210/pdb2dw0/pdb
• 関連するPDBエントリー: 2DW1 2DW2
• 分子名称: Catrocollastatin, alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)][alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: apoptotic toxin, svmp, metalloproteinase, apoptosis, toxin
• 由来する生物種: Crotalus atrox (western diamondback rattlesnake)
• 細胞内の位置: Secreted: Q90282
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 97039.62

構造登録者

Takeda, S.,Igarashi, T.,Araki, S. (登録日: 2006-08-02, 公開日: 2007-07-10, 最終更新日: 2024-10-30)

主引用文献

Igarashi, T.,Araki, S.,Mori, H.,Takeda, S.
Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins
Febs Lett., 581:2416-2422, 2007

PubMed Abstract: Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a metalloproteinase from Crotalus atrox venom, possessing metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the typical domain architecture of a disintegrin and metalloproteinase (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the monomeric class of this family of proteins. The overall structures show good agreement with both monomers of atypical homodimeric VAP1. Comparison of the six catrocollastatin/VAP2B monomer structures and the structures of VAP1 reveals a dynamic, modular architecture that may be important for the functions of ADAM/adamalysin/reprolysin family proteins.

PubMed: 17485084
DOI: 10.1016/j.febslet.2007.04.057

実験手法

X-RAY DIFFRACTION (2.15 Å)