2DUV

Structure of CDK2 with a 3-hydroxychromones

2DUV の概要

• エントリーDOI: 10.2210/pdb2duv/pdb
• 分子名称: Cell division protein kinase 2, 2-(3,4-DIHYDROXYPHENYL)-8-(1,1-DIOXIDOISOTHIAZOLIDIN-2-YL)-3-HYDROXY-6-METHYL-4H-CHROMEN-4-ONE (3 entities in total)
• 機能のキーワード: protein kinase, serine/threonine-protein kinase, cell division, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34379.89

構造登録者

Kim, K.H.,Lee, J.,Park, T.,Jeong, S.,Hong, C. (登録日: 2006-07-27, 公開日: 2007-01-27, 最終更新日: 2024-03-13)

主引用文献

Lee, J.,Park, T.,Jeong, S.,Kim, K.H.,Hong, C.
3-Hydroxychromones as cyclin-dependent kinase inhibitors: synthesis and biological evaluation.
Bioorg.Med.Chem.Lett., 17:1284-1287, 2007

PubMed Abstract: A novel series of 3-hydroxychromones were prepared and found to be CDK inhibitors. Isothiazolidine 1,1-dioxide analogues showed potent CDK1 and CDK2 inhibitory activities and inhibited proliferation of EJ, HCT116, SW620, and MDAMB468 cancer cells.

PubMed: 17178224
DOI: 10.1016/j.bmcl.2006.12.011

実験手法

X-RAY DIFFRACTION (2.2 Å)