2DDE

Structure of cinnamycin complexed with lysophosphatidylethanolamine

2DDE の概要

• エントリーDOI: 10.2210/pdb2dde/pdb
• 関連するPDBエントリー: 1AJ1 1MQX 1MQY 1MQZ 1QOW 1W9N 1WCO 2KTN 2KTO
• 関連するBIRD辞書のPRD_ID: PRD_000195
• 分子名称: LANTIBIOTIC CINNAMYCIN, (7S)-4,7-DIHYDROXY-10-OXO-3,5,9-TRIOXA-4-PHOSPHAUNDECAN-1-AMINIUM 4-OXIDE (2 entities in total)
• 機能のキーワード: antibiotic, immunopotentiator, antimicrobial, antitumor, lipid binding, phosphatidylethanolamine, lanthionine, thioester
• 由来する生物種: STREPTOMYCES GRISEOVERTICILLATUS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2325.56

構造登録者

Hosoda, K.,Ohya, M.,Kohno, T.,Maeda, T.,Endo, S.,Wakamatsu, K. (登録日: 2006-01-27, 公開日: 2006-02-21, 最終更新日: 2024-11-06)

主引用文献

Hosoda, K.,Ohya, M.,Kohno, T.,Maeda, T.,Endo, S.,Wakamatsu, K.
Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1.
J.Biochem., 119:226-230, 1996

PubMed Abstract: The three-dimensional structure of a complex of cinnamycin, a 19-amino acid residue immunopotentiator peptide, and lysophosphatidylethanolamine was determined by 1H-NMR. The complex was cylindrical in shape, 11 A in diameter and 26 A in length, excluding the acyl chain of the phospholipid. The peptide had a hydrophobic pocket surrounded by residues Phe-7 through Ala(S)-14 to bind to the head group of the ligand. Fitting of the head group to the hydrophobic pocket was so good that other than a glycerophosphoethanolamine head group would be unable to fit the pocket. The goodness of the fitting is compatible with the strict specificity of ligand binding of the peptide.

PubMed: 8882709
DOI: 10.1093/oxfordjournals.jbchem.a021226

実験手法

SOLUTION NMR