2D94
THE CONFORMATION OF THE DNA DOUBLE HELIX IN THE CRYSTAL IS DEPENDENT ON ITS ENVIRONMENT
Summary for 2D94
| Entry DOI | 10.2210/pdb2d94/pdb |
| Descriptor | DNA (5'-D(*GP*GP*GP*CP*GP*CP*CP*C)-3') (2 entities in total) |
| Functional Keywords | a-dna, double helix, dna |
| Total number of polymer chains | 1 |
| Total formula weight | 2428.59 |
| Authors | Shakked, Z.,Guerstein-Guzikevich, G.,Eisenstein, M.,Frolow, F.,Rabinovich, D. (deposition date: 1993-07-13, release date: 1994-01-15, Last modification date: 2024-02-14) |
| Primary citation | Shakked, Z.,Guerstein-Guzikevich, G.,Eisenstein, M.,Frolow, F.,Rabinovich, D. The conformation of the DNA double helix in the crystal is dependent on its environment. Nature, 342:456-460, 1989 Cited by PubMed Abstract: Studies of the crystal structures of more than 30 synthetic DNA fragments have provided structural information about three basic forms of the double helix: A-, B- and Z-form DNA. These studies have demonstrated that the DNA double helix adopts a highly variable structure which is related to its base sequence. The extent to which such observed structures are influenced by the crystalline environment can be found by studying the same molecule in different crystalline forms. We have recently crystallized one particular oligomer in various crystal forms. Here we report the results of structural analyses of the different crystal structures and demonstrate that the DNA double helix can adopt a range of conformations in the crystalline state depending on hydration, molecular packing and temperature. These results have implications on our understanding of the influence of the environment on DNA structure, and on the modes of DNA recognition by proteins. PubMed: 2586615DOI: 10.1038/342456a0 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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