2D4R

Crystal structure of TTHA0849 from Thermus thermophilus HB8

2D4R の概要

• エントリーDOI: 10.2210/pdb2d4r/pdb
• 分子名称: hypothetical protein TTHA0849, SULFATE ION (3 entities in total)
• 機能のキーワード: start domain, structural genomics, riken structural genomics/proteomics initiative, rsgi, unknown function
• 由来する生物種: Thermus thermophilus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 69089.10

構造登録者

Nakabayashi, M.,Shibata, N.,Kuramitsu, S.,Higuchi, Y.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (登録日: 2005-10-23, 公開日: 2005-12-13, 最終更新日: 2024-10-23)

主引用文献

Nakabayashi, M.,Shibata, N.,Komori, H.,Ueda, Y.,Iino, H.,Ebihara, A.,Kuramitsu, S.,Higuchi, Y.
Structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, at 2.4 A resolution: a putative member of the StAR-related lipid-transfer (START) domain superfamily.
Acta Crystallogr.,Sect.F, 61:1027-1031, 2005

PubMed Abstract: The crystal structure of a conserved hypothetical protein, TTHA0849 from Thermus thermophilus HB8, has been determined at 2.4 A resolution as a part of a structural and functional genomics project on T. thermophilus HB8. The main-chain folding shows a compact alpha+beta motif, forming a hydrophobic cavity in the molecule. A structural similarity search reveals that it resembles those steroidogenic acute regulatory proteins that contain the lipid-transfer (START) domain, even though TTHA0849 shows comparatively weak sequence identity to polyketide cyclases. However, the size of the ligand-binding cavity is distinctly smaller than other START domain-containing proteins, suggesting that it catalyses the transfer of smaller ligand molecules.

PubMed: 16511226
DOI: 10.1107/S1744309105035372

実験手法

X-RAY DIFFRACTION (2.4 Å)