2D47

MOLECULAR STRUCTURE OF A COMPLETE TURN OF A-DNA

Summary for 2D47

• Entry DOI: 10.2210/pdb2d47/pdb
• Descriptor: DNA (5'-D(*CP*CP*CP*CP*CP*GP*CP*GP*GP*GP*GP*G)-3'), SPERMINE (3 entities in total)
• Functional Keywords: a-dna, double helix, dna
• Total number of polymer chains: 2
• Total formula weight: 7533.08

Authors

Verdaguer, N.,Aymami, J.,Fernandez-Forner, D.,Fita, I.,Coll, M.,Huynh-Dinh, T.,Igolen, J.,Subirana, J.A. (deposition date: 1991-10-02, release date: 1991-10-02, Last modification date: 2024-02-14)

Primary citation

Verdaguer, N.,Aymami, J.,Fernandez-Forner, D.,Fita, I.,Coll, M.,Huynh-Dinh, T.,Igolen, J.,Subirana, J.A.
Molecular structure of a complete turn of A-DNA.
J.Mol.Biol., 221:623-635, 1991

PubMed Abstract: We have determined the crystal structure of the dodecamer d(CCCCCGCGGGGG), showing for the first time a complete turn of A-DNA. It has average structural parameters similar to those determined in fibres. Nevertheless it shows a considerable local variation in structure which is in part associated with the presence of a bound spermine molecule. We conclude that the local DNA conformation does not only depend on the base sequence, but may be strongly modified upon interaction with other molecules. In particular, the CpG sequence, which is found in hypersensitive regions of the genome, appears to be able to easily change its conformation under external influences.

PubMed: 1920437
DOI: 10.1016/0022-2836(91)80077-8

Experimental method

X-RAY DIFFRACTION (2 Å)