2D2X

Crystal structure of 2-deoxy-scyllo-inosose synthase

2D2X の概要

• エントリーDOI: 10.2210/pdb2d2x/pdb
• 分子名称: 2-deoxy-scyllo-inosose synthase, COBALT (II) ION, SULFITE ION, ... (5 entities in total)
• 機能のキーワード: aminoglycoside, 2-deoxystreptamine, dehydroquinate synthase, lyase
• 由来する生物種: Bacillus circulans
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82257.78

構造登録者

Nango, E.,Kumasaka, T.,Tanaka, N.,Kakinuma, K.,Eguchi, T. (登録日: 2005-09-20, 公開日: 2006-10-03, 最終更新日: 2011-07-13)

• 主引用文献: Nango, E.,Kumasaka, T.,Hirayama, T.,Tanaka, N.,Eguchi, T.; Structure of 2-deoxy-scyllo-inosose synthase, a key enzyme in the biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics, in complex with a mechanism-based inhibitor and NAD+; Proteins, 70:517-527, 2008; PubMed: 17879343; DOI: 10.1002/prot.21526

実験手法

X-RAY DIFFRACTION (2.3 Å)