2D26

Active site distortion is sufficient for proteinase inhibit second crystal structure of covalent serpin-proteinase complex

2D26 の概要

• エントリーDOI: 10.2210/pdb2d26/pdb
• 分子名称: Alpha-1-antitrypsin, Elastase-1, ... (4 entities in total)
• 機能のキーワード: serpine proteinase, serpin, covalent serpin-proteinase comp protein-protein interactions, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted. Short peptide from AAT: Secreted, extracellular space, extracellular matrix: P01009 P01009; Secreted: P00772
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 70178.27

構造登録者

Dementiev, A.,Dobo, J.,Gettins, P.G. (登録日: 2005-09-03, 公開日: 2005-11-29, 最終更新日: 2023-10-25)

• 主引用文献: Dementiev, A.,Dobo, J.,Gettins, P.G.; Active Site Distortion Is Sufficient for Proteinase Inhibition by Serpins: Structure of the covalent complex of alpha 1-proteinase inhibitor with porcine pancreatic elastase; J.Biol.Chem., 281:3452-3457, 2006; PubMed: 16321984; DOI: 10.1074/jbc.M510564200

実験手法

X-RAY DIFFRACTION (3.3 Å)