2CW6

Crystal Structure of Human HMG-CoA Lyase: Insights into Catalysis and the Molecular Basis for Hydroxymethylglutaric Aciduria

Summary for 2CW6

Entry DOI	10.2210/pdb2cw6/pdb
Descriptor	Hydroxymethylglutaryl-CoA lyase, mitochondrial, MAGNESIUM ION, 3-HYDROXYPENTANEDIOIC ACID, ... (4 entities in total)
Functional Keywords	hmg-coa lyase, ketogenic enzyme, lyase
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion matrix: P35914
Total number of polymer chains	6
Total formula weight	189759.71
Authors	Fu, Z.,Runquist, J.A.,Hunt, J.F.,Miziorko, H.M.,Kim, J.-J.P. (deposition date: 2005-06-17, release date: 2005-12-06, Last modification date: 2024-03-13)
Primary citation	Fu, Z.,Runquist, J.A.,Forouhar, F.,Hussain, M.,Hunt, J.F.,Miziorko, H.M.,Kim, J.-J.P. Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria J.Biol.Chem., 281:7526-7532, 2006 Cited by PubMed: 16330550 DOI: 10.1074/jbc.M506880200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation