2CW6

Crystal Structure of Human HMG-CoA Lyase: Insights into Catalysis and the Molecular Basis for Hydroxymethylglutaric Aciduria

2CW6 の概要

• エントリーDOI: 10.2210/pdb2cw6/pdb
• 分子名称: Hydroxymethylglutaryl-CoA lyase, mitochondrial, MAGNESIUM ION, 3-HYDROXYPENTANEDIOIC ACID, ... (4 entities in total)
• 機能のキーワード: hmg-coa lyase, ketogenic enzyme, lyase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion matrix: P35914
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 189759.71

構造登録者

Fu, Z.,Runquist, J.A.,Hunt, J.F.,Miziorko, H.M.,Kim, J.-J.P. (登録日: 2005-06-17, 公開日: 2005-12-06, 最終更新日: 2024-03-13)

• 主引用文献: Fu, Z.,Runquist, J.A.,Forouhar, F.,Hussain, M.,Hunt, J.F.,Miziorko, H.M.,Kim, J.-J.P.; Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria; J.Biol.Chem., 281:7526-7532, 2006; PubMed: 16330550; DOI: 10.1074/jbc.M506880200

実験手法