2CL5
Catechol-O-methyltransferase in complex with an inhibitor
Summary for 2CL5
Entry DOI | 10.2210/pdb2cl5/pdb |
Descriptor | CATECHOL O-METHYLTRANSFERASE, MAGNESIUM ION, S-ADENOSYLMETHIONINE, ... (7 entities in total) |
Functional Keywords | transferase, alternative initiation, catecholamine metabolism, neurotransmitter degradation, catechol-o-methyltransferase, phosphorylation, methyltransferase, signal-anchor, transmembrane, comt inhibitor, membrane, magnesium, metal-binding |
Biological source | RATTUS NORVEGICUS (RAT) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734 |
Total number of polymer chains | 2 |
Total formula weight | 51374.31 |
Authors | Palma, P.N.,Rodrigues, M.L.,Archer, M.,Bonifacio, M.J.,Loureiro, A.I.,Learmonth, D.A.,Carrondo, M.A.,Soares-Da-Silva, P. (deposition date: 2006-04-26, release date: 2006-06-28, Last modification date: 2023-12-13) |
Primary citation | Palma, P.N.,Rodrigues, M.L.,Archer, M.,Bonifacio, M.J.,Loureiro, A.I.,Learmonth, D.A.,Carrondo, M.A.,Soares-Da-Silva, P. Comparative Study of Ortho- and Meta-Nitrated Inhibitors of Catechol-O-Methyltransferase: Interactions with the Active Site and Regioselectivity of O-Methylation. Mol.Pharmacol., 70:143-, 2006 Cited by PubMed: 16618795DOI: 10.1124/MOL.106.023119 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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