2CL5

Catechol-O-methyltransferase in complex with an inhibitor

2CL5 の概要

• エントリーDOI: 10.2210/pdb2cl5/pdb
• 分子名称: CATECHOL O-METHYLTRANSFERASE, MAGNESIUM ION, S-ADENOSYLMETHIONINE, ... (7 entities in total)
• 機能のキーワード: transferase, alternative initiation, catecholamine metabolism, neurotransmitter degradation, catechol-o-methyltransferase, phosphorylation, methyltransferase, signal-anchor, transmembrane, comt inhibitor, membrane, magnesium, metal-binding
• 由来する生物種: RATTUS NORVEGICUS (RAT)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 51374.31

構造登録者

Palma, P.N.,Rodrigues, M.L.,Archer, M.,Bonifacio, M.J.,Loureiro, A.I.,Learmonth, D.A.,Carrondo, M.A.,Soares-Da-Silva, P. (登録日: 2006-04-26, 公開日: 2006-06-28, 最終更新日: 2023-12-13)

• 主引用文献: Palma, P.N.,Rodrigues, M.L.,Archer, M.,Bonifacio, M.J.,Loureiro, A.I.,Learmonth, D.A.,Carrondo, M.A.,Soares-Da-Silva, P.; Comparative Study of Ortho- and Meta-Nitrated Inhibitors of Catechol-O-Methyltransferase: Interactions with the Active Site and Regioselectivity of O-Methylation.; Mol.Pharmacol., 70:143-, 2006; PubMed: 16618795; DOI: 10.1124/MOL.106.023119

実験手法

X-RAY DIFFRACTION (1.6 Å)