2CJT

Structural Basis for a Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules

Summary for 2CJT

• Entry DOI: 10.2210/pdb2cjt/pdb
• Related: 1Y8F 2CJS
• Descriptor: UNC-13 HOMOLOG A, 1,2-ETHANEDIOL, FORMIC ACID, ... (4 entities in total)
• Functional Keywords: phorbol-ester binding, neurotransmitter release, rim, munc13, c2 domains, exocytosis, metal-binding, protein-protein interactions, zinc finger, synaptosome
• Biological source: RATTUS NORVEGICUS (RAT)
• Total number of polymer chains: 4
• Total formula weight: 60981.19

Authors

Lu, J.,Machius, M.,Dulubova, I.,Dai, H.,Sudhof, T.C.,Tomchick, D.R.,Rizo, J. (deposition date: 2006-04-06, release date: 2006-06-07, Last modification date: 2019-01-30)

• Primary citation: Lu, J.,Machius, M.,Dulubova, I.,Dai, H.,Sudhof, T.C.,Tomchick, D.R.,Rizo, J.; Structural Basis for a Munc13-1 Dimeric to Munc13-1/Rim Heterodimer Switch; Plos Biol., 4:E192-, 2006; PubMed: 16732694; DOI: 10.1371/JOURNAL.PBIO.0040192

Experimental method

X-RAY DIFFRACTION (1.44 Å)