2CHW

A pharmacological map of the PI3-K family defines a role for p110 alpha in signaling: The structure of complex of phosphoinositide 3- kinase gamma with inhibitor PIK-39

2CHW の概要

• エントリーDOI: 10.2210/pdb2chw/pdb
• 関連するPDBエントリー: 1E8Y 1E8Z 1HE8 2A4Z 2A5U 2CHX 2CHZ
• 分子名称: PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, 2-((9H-PURIN-6-YLTHIO)METHYL)-5-CHLORO-3-(2-METHOXYPHENYL)QUINAZOLIN-4(3H)-ONE (3 entities in total)
• 機能のキーワード: transferase/inhibitor, complex transferase-inhibitor, phosphoinositide, kinase, lipid, inhibitor, 3-kinase, signaling, quinazolinone, transferase, transferase-inhibitor complex
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 111207.07

構造登録者

Knight, Z.A.,Gonzalez, B.,Feldman, M.E.,Zunder, E.R.,Goldenberg, D.D.,Williams, O.,Loewith, R.,Stokoe, D.,Balla, A.,Toth, B.,Balla, T.,Weiss, W.A.,Williams, R.L.,Shokat, K.M. (登録日: 2006-03-16, 公開日: 2006-05-22, 最終更新日: 2023-12-13)

• 主引用文献: Knight, Z.A.,Gonzalez, B.,Feldman, M.E.,Zunder, E.R.,Goldenberg, D.D.,Williams, O.,Loewith, R.,Stokoe, D.,Balla, A.,Toth, B.,Balla, T.,Weiss, W.A.,Williams, R.L.,Shokat, K.M.; A Pharmacological Map of the Pi3-K Family Defines a Role for P110Alpha in Signaling; Cell(Cambridge,Mass.), 125:733-, 2006; PubMed: 16647110; DOI: 10.1016/J.CELL.2006.03.035

実験手法

X-RAY DIFFRACTION (2.6 Å)