2CE4

Manganese Superoxide Dismutase (Mn-SOD) from Deinococcus radiodurans

Summary for 2CE4

• Entry DOI: 10.2210/pdb2ce4/pdb
• Related: 1Y67 2CDY
• Descriptor: SUPEROXIDE DISMUTASE [MN], MANGANESE (II) ION (3 entities in total)
• Functional Keywords: manganese superoxide dismutase, deinococcus radiodurans, radiation resistance, oxidoreductase
• Biological source: DEINOCOCCUS RADIODURANS
• Total number of polymer chains: 2
• Total formula weight: 52075.63

Authors

Dennis, R.,Micossi, E.,McCarthy, J.,Moe, E.,Gordon, E.,Leonard, G.,McSweeney, S. (deposition date: 2006-02-03, release date: 2006-02-13, Last modification date: 2023-12-13)

Primary citation

Dennis, R.J.,Micossi, E.,McCarthy, J.,Moe, E.,Gordon, E.J.,Kozielski-Stuhrmann, S.,Leonard, G.A.,McSweeney, S.
Structure of the manganese superoxide dismutase from Deinococcus radiodurans in two crystal forms.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun., 62:325-329, 2006

PubMed Abstract: The structure of the manganese superoxide dismutase (Mn-SOD; DR1279) from Deinococcus radiodurans has been determined in two different crystal forms. Both crystal forms are monoclinic with space group P2(1). Form I has unit-cell parameters a = 44.28, b = 83.21, c = 59.52 angstroms, beta = 110.18 degrees and contains a homodimer in the asymmetric unit, with structure refinement (R = 16.8%, R(free) = 23.6%) carried out using data to d(min) = 2.2 angstroms. Form II has unit-cell parameters a = 43.57, b = 87.10, c = 116.42 angstroms, beta = 92.1 degrees and an asymmetric unit containing two Mn-SOD homodimers; structure refinement was effected to a resolution of 2.0 angstroms (R = 17.2%, R(free) = 22.3%). The resulting structures are compared with that of Mn-SOD from Escherichia coli, with which they are shown to be essentially isostructural.

PubMed: 16582477
DOI: 10.1107/S1744309106008402

Experimental method

X-RAY DIFFRACTION (2.2 Å)