2CAS

THE CANINE PARVOVIRUS EMPTY CAPSID STRUCTURE

2CAS の概要

• エントリーDOI: 10.2210/pdb2cas/pdb
• 分子名称: CANINE PARVOVIRUS EMPTY CAPSID (STRAIN D) VIRAL PROTEIN 2 (2 entities in total)
• 機能のキーワード: parvovirus coat protein, icosahedral virus, virus
• 由来する生物種: Canine parvovirus
• 細胞内の位置: Virion (By similarity): Q11213
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61562.37

構造登録者

Wu, H.,Rossmann, M.G. (登録日: 1993-08-24, 公開日: 1994-01-31, 最終更新日: 2024-10-23)

主引用文献

Wu, H.,Rossmann, M.G.
The canine parvovirus empty capsid structure.
J.Mol.Biol., 233:231-244, 1993

PubMed Abstract: The structure of empty canine parvovirus capsids shows that residues 37 to the carboxy-terminal residue 584 (VP2 numbering) are ordered in each of the 60 subunits. The central structural motif of each subunit is the eight-stranded antiparallel beta-barrel that has been found in many other virus structures. Five beta-hairpin turns form a beta-cylindrical structure at each icosahedral 5-fold axis. The N-terminal glycine-rich sequence can be accommodated within this cylinder without excessive steric hindrance, consistent with the electron density distribution. By far the largest conformational differences between the full and empty virus were found in the region where some ordered DNA has been observed to bind in canine parvovirus full particles. Extensive interactions among 3-fold related subunits indicate that a trimeric subunit might be a viral assembly intermediate.

PubMed: 8377200
DOI: 10.1006/jmbi.1993.1502

実験手法

X-RAY DIFFRACTION (3 Å)