2C8I

Complex Of Echovirus Type 12 With Domains 1, 2, 3 and 4 Of Its Receptor Decay Accelerating Factor (Cd55) By Cryo Electron Microscopy At 16 A

Summary for 2C8I

• Entry DOI: 10.2210/pdb2c8i/pdb
• Related: 1H03 1H04 1H2P 1H2Q 1M11 1NWV 1OJV 1OJW 1OJY 1OK1 1OK2 1OK3 1OK9 1UOT 1UPN
• EMDB information: 1182 1183
• Descriptor: ECHOVIRUS 11 COAT PROTEIN VP1, ECHOVIRUS 11 COAT PROTEIN VP2, ECHOVIRUS 11 COAT PROTEIN VP3, ... (5 entities in total)
• Functional Keywords: picornavirus, daf, virus-receptor complex, antigen, blood group antigen, complement pathway, gpi-anchor, immune response, innate immunity, lipoprotein, plasma, sushi, virus/receptor
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Capsid protein VP0: Virion . Capsid protein VP4: Virion . Capsid protein VP2: Virion . Capsid protein VP3: Virion . Capsid protein VP1: Virion . Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3AB: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Viral protein genome-linked: Virion . Protease 3C: Host cytoplasm . Protein 3CD: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P29813 P29813 P29813 P29813; Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Lipid-anchor, GPI- anchor. Isoform 3: Secreted . Isoform 4: Secreted . Isoform 5: Secreted . Isoform 6: Cell membrane ; Lipid-anchor, GPI-anchor . Isoform 7: Cell membrane ; Lipid-anchor, GPI-anchor : P08174
• Total number of polymer chains: 5
• Total formula weight: 127995.66

Authors

Pettigrew, D.M.,Williams, D.T.,Kerrigan, D.,Evans, D.J.,Lea, S.M.,Bhella, D. (deposition date: 2005-12-05, release date: 2006-01-17, Last modification date: 2017-08-30)

• Primary citation: Pettigrew, D.M.,Williams, D.T.,Kerrigan, D.,Evans, D.J.,Lea, S.M.,Bhella, D.; Structural and Functional Insights Into the Interaction of Echoviruses and Decay-Accelerating Factor.; J.Biol.Chem., 281:5169-, 2006; PubMed: 16272562; DOI: 10.1074/JBC.M510362200

Experimental method

ELECTRON MICROSCOPY (14 Å)