2C70

Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins

2C70 の概要

• エントリーDOI: 10.2210/pdb2c70/pdb
• 関連するPDBエントリー: 1GOS 1H8R 1OJ9 1OJA 1OJB 1OJC 1OJD 1S2Q 1S2Y 1S3B 1S3E 2BK3 2BK4 2BK5 2BYB 2C64 2C65 2C66 2C67 2C72 2C73 2C75 2C76
• 分子名称: AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE, P-NITRO-BENZYLAMINE, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, enantioselectivity, fad, flavin, flavoprotein, human monoamine oxidase, inhibitor binding, mitochondrion, rasagiline, transmembrane, parkinson
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side: P27338
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 119550.86

構造登録者

Li, M.,Binda, C.,Mattevi, A.,Edmondson, D.E. (登録日: 2005-11-17, 公開日: 2006-04-19, 最終更新日: 2023-12-13)

• 主引用文献: Li, M.,Binda, C.,Mattevi, A.,Edmondson, D.E.; Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins; Biochemistry, 45:4775-, 2006; PubMed: 16605246; DOI: 10.1021/BI051847G

実験手法

X-RAY DIFFRACTION (2.06 Å)