2C6P

Membrane-bound glutamate carboxypeptidase II (GCPII) in complex with phosphate anion

2C6P の概要

• エントリーDOI: 10.2210/pdb2c6p/pdb
• 関連するPDBエントリー: 1Z8L 2C6C 2C6G
• 分子名称: GLUTAMATE CARBOXYPEPTIDASE II, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: naaladase, neurodegenerative disease, peptidase, prostate cancer, psma, glycoprotein, hydrolase, alternative splicing, antigen, carboxypeptidase, dipeptidase, metal-binding, metalloprotease, multifunctional enzyme, polymorphism, signal-anchor, transmembrane, zinc
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 81793.83

構造登録者

Mesters, J.R.,Barinka, C.,Li, W.,Tsukamoto, T.,Majer, P.,Slusher, B.S.,Konvalinka, J.,Hilgenfeld, R. (登録日: 2005-11-11, 公開日: 2006-02-15, 最終更新日: 2020-07-29)

• 主引用文献: Mesters, J.R.,Barinka, C.,Li, W.,Tsukamoto, T.,Majer, P.,Slusher, B.S.,Konvalinka, J.,Hilgenfeld, R.; Structure of Glutamate Carboxypeptidase II, a Drug Target in Neuronal Damage and Prostate Cancer.; Embo J., 25:1375-, 2006; PubMed: 16467855; DOI: 10.1038/SJ.EMBOJ.7600969

実験手法

X-RAY DIFFRACTION (2.39 Å)