2C0M

apo form of the TPR domain of the pex5p receptor

2C0M の概要

• エントリーDOI: 10.2210/pdb2c0m/pdb
• 関連するPDBエントリー: 1FCH 2C0L
• 分子名称: PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR (2 entities in total)
• 機能のキーワード: transport protein, tpr repeat, transport, import receptor complex, peroxisome, disease mutation, protein transport, zellweger syndrome
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm: P50542
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 140986.80

構造登録者

Stanley, W.A.,Kursula, P.,Wilmanns, M. (登録日: 2005-09-05, 公開日: 2006-11-15, 最終更新日: 2024-05-08)

主引用文献

Stanley, W.A.,Filipp, F.V.,Kursula, P.,Schuller, N.,Erdmann, R.,Schliebs, W.,Sattler, M.,Wilmanns, M.
Recognition of a Functional Peroxisome Type 1 Target by the Dynamic Import Receptor Pex5P.
Mol.Cell, 24:653-, 2006

PubMed Abstract: Peroxisomes require the translocation of folded and functional target proteins of various sizes across the peroxisomal membrane. We have investigated the structure and function of the principal import receptor Pex5p, which recognizes targets bearing a C-terminal peroxisomal targeting signal type 1. Crystal structures of the receptor in the presence and absence of a peroxisomal target, sterol carrier protein 2, reveal major structural changes from an open, snail-like conformation into a closed, circular conformation. These changes are caused by a long loop C terminal to the 7-fold tetratricopeptide repeat segments. Mutations in residues of this loop lead to defects in peroxisomal import in human fibroblasts. The structure of the receptor/cargo complex demonstrates that the primary receptor-binding site of the cargo is structurally and topologically autonomous, enabling the cargo to retain its native structure and function.

PubMed: 17157249
DOI: 10.1016/J.MOLCEL.2006.10.024

実験手法

X-RAY DIFFRACTION (2.5 Å)