2BZV

Human Enteric Adenovirus Serotype 41 Short Fiber Head (pH8)

2BZV の概要

• エントリーDOI: 10.2210/pdb2bzv/pdb
• 関連するPDBエントリー: 2BZU
• 分子名称: FIBER PROTEIN 2 (2 entities in total)
• 機能のキーワード: adenovirus, fiber, receptor, ad41, fiber protein, viral protein
• 由来する生物種: HUMAN ADENOVIRUS TYPE 41
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20148.71

構造登録者

Seiradake, E.,Cusack, S. (登録日: 2005-08-23, 公開日: 2005-09-16, 最終更新日: 2023-12-13)

主引用文献

Seiradake, E.,Cusack, S.
Crystal Structure of Enteric Adenovirus Serotype 41 Short Fiber Head.
J.Virol., 79:14088-, 2005

PubMed Abstract: Human enteric adenoviruses of species F contain two fibers in the same virion, a long fiber which binds to coxsackievirus and adenovirus receptor (CAR) and a short fiber of unknown function. We have determined the high-resolution crystal structure of the short fiber head of human adenovirus serotype 41 (Ad41). The short fiber head has the characteristic fold of other known fiber heads but has three unusual features. First, it has much shorter loops between the beta-strands. Second, one of the usually well-ordered beta-strands on the distal face of the fiber head is highly disordered and this same region is sensitive to digestion with pepsin, an enzyme occurring naturally in the intestinal tract, the physiological environment of Ad41. Third, the AB loop has a deletion giving it a distinct conformation incompatible with CAR binding.

PubMed: 16254343
DOI: 10.1128/JVI.79.22.14088-14094.2005

実験手法

X-RAY DIFFRACTION (1.15 Å)