2BUD

The solution structure of the chromo barrel domain from the males- absent on the first (MOF) protein

2BUD の概要

• エントリーDOI: 10.2210/pdb2bud/pdb
• 分子名称: MALES-ABSENT ON THE FIRST PROTEIN (1 entity in total)
• 機能のキーワード: transferase, mof, hat, acetyl-transfer, dosage compensation complex, dcc, royal family, chromodomain like, beta barrel, transferase acyltransferase, metal-binding
• 由来する生物種: DROSOPHILA MELANOGASTER (FRUIT FLY)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10352.49

構造登録者

Nielsen, P.R.,Nietlispach, D.,Buscaino, A.,Warner, R.J.,Akhtar, A.,Murzin, A.G.,Murzina, N.V.,Laue, E.D. (登録日: 2005-06-09, 公開日: 2005-06-24, 最終更新日: 2024-05-15)

主引用文献

Nielsen, P.R.,Nietlispach, D.,Buscaino, A.,Warner, R.J.,Akhtar, A.,Murzin, A.G.,Murzina, N.V.,Laue, E.D.
Structure of the Chromo Barrel Domain from the Mof Acetyltransferase
J.Biol.Chem., 280:32326-, 2005

PubMed Abstract: We report here the structure of the putative chromo domain from MOF, a member of the MYST family of histone acetyltransferases that acetylates histone H4 at Lys-16 and is part of the dosage compensation complex in Drosophila. We found that the structure of this domain is a beta-barrel that is distinct from the alpha + beta fold of the canonical chromo domain. Despite the differences, there are similarities that support an evolutionary relationship between the two domains, and we propose the name "chromo barrel." The chromo barrel domains may be divided into two groups, MSL3-like and MOF-like, on the basis of whether a group of conserved aromatic residues is present or not. The structure suggests that, although the MOF-like domains may have a role in RNA binding, the MSL3-like domains could instead bind methylated residues. The MOF chromo barrel shares a common fold with other chromatin-associated modules, including the MBT-like repeat, Tudor, and PWWP domains. This structural similarity suggests a probable evolutionary pathway from these other modules to the canonical chromo domains (or vice versa) with the chromo barrel domain representing an intermediate structure.

PubMed: 15964847
DOI: 10.1074/JBC.M501347200

実験手法

SOLUTION NMR