2BTF

THE STRUCTURE OF CRYSTALLINE PROFILIN-BETA-ACTIN

2BTF の概要

• エントリーDOI: 10.2210/pdb2btf/pdb
• 分子名称: BETA-ACTIN, PROFILIN, STRONTIUM ION, ... (4 entities in total)
• 機能のキーワード: acetylation and actin-binding
• 由来する生物種: Bos taurus (cattle); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton: P60712 P02584
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57253.51

構造登録者

Schutt, C.E.,Myslik, J.C.,Rozycki, M.D.,Goonesekere, N.C.W. (登録日: 1994-01-18, 公開日: 1994-06-22, 最終更新日: 2025-03-26)

主引用文献

Schutt, C.E.,Myslik, J.C.,Rozycki, M.D.,Goonesekere, N.C.,Lindberg, U.
The structure of crystalline profilin-beta-actin.
Nature, 365:810-816, 1993

PubMed Abstract: The three-dimensional structure of bovine profilin-beta-actin has been solved to 2.55 A resolution by X-ray crystallography. There are several significant local changes in the structure of beta-actin compared with alpha-actin as well as an overall 5 degrees rotation between its two major domains. Actin molecules in the crystal are organized into ribbons through intermolecular contacts like those found in oligomeric protein assemblies. Profilin forms two extensive contacts with the actin ribbon, one of which appears to correspond to the solution contact in vitro.

PubMed: 8413665
DOI: 10.1038/365810a0

実験手法

X-RAY DIFFRACTION (2.55 Å)