2BT4

Type II Dehydroquinase inhibitor complex

2BT4 の概要

• エントリーDOI: 10.2210/pdb2bt4/pdb
• 関連するPDBエントリー: 1D0I 1GTZ 1GU0 1GU1 1V1J
• 分子名称: 3-DEHYDROQUINATE DEHYDRATASE, (1S,3R,4R,5S)-1,3,4-TRIHYDROXY-5-(3-PHENOXYPROPYL)CYCLOHEXANECARBOXYLIC ACID, PHOSPHATE ION, ... (6 entities in total)
• 機能のキーワード: shikimate pathway, dehydroquinate, lyase, amino-acid biosynthesis, aromatic amino acid biosynthesis
• 由来する生物種: STREPTOMYCES COELICOLOR
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 206107.30

構造登録者

Toscano, M.D.,Stewart, K.A.,Coggins, J.R.,Lapthorn, A.J.,Abell, C. (登録日: 2005-05-26, 公開日: 2006-02-13, 最終更新日: 2023-12-13)

主引用文献

Toscano, M.D.,Stewart, K.A.,Coggins, J.R.,Lapthorn, A.J.,Abell, C.
Rational Design of New Bifunctional Inhibitors of Type II Dehydroquinase.
Org.Biomol.Chem., 3:3102-, 2005

PubMed Abstract: Selective inhibitors of type II dehydroquinase were rationally designed to explore a second binding-pocket in the active-site. The molecular modelling, synthesis, inhibition studies and crystal structure determination are described.

PubMed: 16106291
DOI: 10.1039/B507156A

実験手法

X-RAY DIFFRACTION (1.7 Å)