2BM2

human beta-II tryptase in complex with 4-(3-Aminomethyl-phenyl)- piperidin-1-yl-(5-phenethyl- pyridin-3-yl)-methanone

Summary for 2BM2

• Entry DOI: 10.2210/pdb2bm2/pdb
• Related: 1A0L 1AAO
• Descriptor: HUMAN BETA2 TRYPTASE, 1-[3-(1-{[5-(2-PHENYLETHYL)PYRIDIN-3-YL]CARBONYL}PIPERIDIN-4-YL)PHENYL]METHANAMINE (3 entities in total)
• Functional Keywords: serine protease inhibitor, glycoprotein, hydrolase, polymorphism, protease, serine protease
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 4
• Total formula weight: 111563.82

Authors

Maignan, S.,Guilloteau, J.-P.,Dupuy, A.,Levell, J.,Astles, P.,Eastwood, P.,Cairns, J.,Houille, O.,Aldous, S.,Merriman, G.,Whiteley, B.,Pribish, J.,Czekaj, M.,Liang, G.,Davidson, J.,Harrison, T.,Morley, A.,Watson, S.,Fenton, G.,Mccarthy, C.,Romano, J.,Mathew, R.,Engers, D.,Gardyan, M.,Sides, K.,Kwong, J.,Tsay, J.,Rebello, S.,Shen, L.,Wang, J.,Luo, Y.,Giardino, O.,Lim, H.-K.,Smith, K.,Pauls, H. (deposition date: 2005-03-09, release date: 2005-03-22, Last modification date: 2023-12-13)

• Primary citation: Levell, J.,Astles, P.,Eastwood, P.,Cairns, J.,Houille, O.,Aldous, S.,Merriman, G.,Whitley, B.,Pribish, J.,Czekaj, M.,Liang, G.,Maignan, S.,Guilloteau, J.-P.,Dupuy, A.,Davidson, J.,Harrison, T.,Morley, A.,Watson, S.,Fenton, G.,Mccarthy, C.,Romano, J.,Mathew, R.,Engers, D.,Gardyan, M.,Sides, K.,Kwong, J.,Tsay, J.,Rebello, S.,Shen, L.,Wang, J.,Luo, Y.,Giardino, O.,Lim, H.-K.,Smith, K.,Pauls, H.; Structure Based Design of 4-(3-Aminomethylphenyl) Piperidinyl-1-Amides: Novel, Potent, Selective, and Orally Bioavailable Inhibitors of Bii Tryptase; Bioorg.Med.Chem., 13:2859-, 2005; PubMed: 15781396; DOI: 10.1016/J.BMC.2005.02.014

Experimental method

X-RAY DIFFRACTION (2.2 Å)