2BM2
human beta-II tryptase in complex with 4-(3-Aminomethyl-phenyl)- piperidin-1-yl-(5-phenethyl- pyridin-3-yl)-methanone
Summary for 2BM2
Entry DOI | 10.2210/pdb2bm2/pdb |
Related | 1A0L 1AAO |
Descriptor | HUMAN BETA2 TRYPTASE, 1-[3-(1-{[5-(2-PHENYLETHYL)PYRIDIN-3-YL]CARBONYL}PIPERIDIN-4-YL)PHENYL]METHANAMINE (3 entities in total) |
Functional Keywords | serine protease inhibitor, glycoprotein, hydrolase, polymorphism, protease, serine protease |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 4 |
Total formula weight | 111563.82 |
Authors | Maignan, S.,Guilloteau, J.-P.,Dupuy, A.,Levell, J.,Astles, P.,Eastwood, P.,Cairns, J.,Houille, O.,Aldous, S.,Merriman, G.,Whiteley, B.,Pribish, J.,Czekaj, M.,Liang, G.,Davidson, J.,Harrison, T.,Morley, A.,Watson, S.,Fenton, G.,Mccarthy, C.,Romano, J.,Mathew, R.,Engers, D.,Gardyan, M.,Sides, K.,Kwong, J.,Tsay, J.,Rebello, S.,Shen, L.,Wang, J.,Luo, Y.,Giardino, O.,Lim, H.-K.,Smith, K.,Pauls, H. (deposition date: 2005-03-09, release date: 2005-03-22, Last modification date: 2023-12-13) |
Primary citation | Levell, J.,Astles, P.,Eastwood, P.,Cairns, J.,Houille, O.,Aldous, S.,Merriman, G.,Whitley, B.,Pribish, J.,Czekaj, M.,Liang, G.,Maignan, S.,Guilloteau, J.-P.,Dupuy, A.,Davidson, J.,Harrison, T.,Morley, A.,Watson, S.,Fenton, G.,Mccarthy, C.,Romano, J.,Mathew, R.,Engers, D.,Gardyan, M.,Sides, K.,Kwong, J.,Tsay, J.,Rebello, S.,Shen, L.,Wang, J.,Luo, Y.,Giardino, O.,Lim, H.-K.,Smith, K.,Pauls, H. Structure Based Design of 4-(3-Aminomethylphenyl) Piperidinyl-1-Amides: Novel, Potent, Selective, and Orally Bioavailable Inhibitors of Bii Tryptase Bioorg.Med.Chem., 13:2859-, 2005 Cited by PubMed: 15781396DOI: 10.1016/J.BMC.2005.02.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report