2BKF

Structure of the PB1 domain of NBR1

Summary for 2BKF

• Entry DOI: 10.2210/pdb2bkf/pdb
• Related: 1WJ6 2CP8
• Descriptor: ZINC-FINGER PROTEIN NBR1 (NEXT TO BREAST CANCER 1), GLYCEROL (3 entities in total)
• Functional Keywords: zinc-finger protein, pb1 domain, nbr1, interaction domain, zinc-finger
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 10055.09

Authors

Mueller, S.,Kursula, I.,Wilmanns, M. (deposition date: 2005-02-16, release date: 2006-01-18, Last modification date: 2024-05-08)

Primary citation

Mueller, S.,Kursula, I.,Zou, P.,Wilmanns, M.
Crystal Structure of the Pb1 Domain of Nbr1
FEBS Lett., 580:341-, 2006

PubMed Abstract: The scaffold protein NBR1 is involved in signal transmission downstream of the serine/protein kinase from the giant muscle protein titin. Its N-terminal Phox and Bem1p (PB1) domain plays a critical role in mediating protein-protein interactions with both titin kinase and with another scaffold protein, p62. We have determined the crystal structure of the PB1 domain of NBR1 at 1.55A resolution. It reveals a type-A PB1 domain with two negatively charged residue clusters. We provide a structural perspective on the involvement of NBR1 in the titin kinase signalling pathway.

PubMed: 16376336
DOI: 10.1016/J.FEBSLET.2005.12.021

Experimental method

X-RAY DIFFRACTION (1.56 Å)