2BKF

Structure of the PB1 domain of NBR1

2BKF の概要

• エントリーDOI: 10.2210/pdb2bkf/pdb
• 関連するPDBエントリー: 1WJ6 2CP8
• 分子名称: ZINC-FINGER PROTEIN NBR1 (NEXT TO BREAST CANCER 1), GLYCEROL (3 entities in total)
• 機能のキーワード: zinc-finger protein, pb1 domain, nbr1, interaction domain, zinc-finger
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10055.09

構造登録者

Mueller, S.,Kursula, I.,Wilmanns, M. (登録日: 2005-02-16, 公開日: 2006-01-18, 最終更新日: 2024-05-08)

主引用文献

Mueller, S.,Kursula, I.,Zou, P.,Wilmanns, M.
Crystal Structure of the Pb1 Domain of Nbr1
FEBS Lett., 580:341-, 2006

PubMed Abstract: The scaffold protein NBR1 is involved in signal transmission downstream of the serine/protein kinase from the giant muscle protein titin. Its N-terminal Phox and Bem1p (PB1) domain plays a critical role in mediating protein-protein interactions with both titin kinase and with another scaffold protein, p62. We have determined the crystal structure of the PB1 domain of NBR1 at 1.55A resolution. It reveals a type-A PB1 domain with two negatively charged residue clusters. We provide a structural perspective on the involvement of NBR1 in the titin kinase signalling pathway.

PubMed: 16376336
DOI: 10.1016/J.FEBSLET.2005.12.021

実験手法

X-RAY DIFFRACTION (1.56 Å)