2BIO

human p53 core domain mutant M133L-V203A-N239Y-R249S-N268D

2BIO の概要

• エントリーDOI: 10.2210/pdb2bio/pdb
• 関連するPDBエントリー: 1A1U 1AIE 1C26 1DT7 1GZH 1H26 1HS5 1JSP 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAG 1SAH 1SAI 1SAJ 1SAK 1SAL 1TSR 1TUP 1UOL 1XQH 1YCQ 1YCR 1YCS 2BIM 2BIN 2BIP 2BIQ 3SAK
• 分子名称: CELLULAR TUMOR ANTIGEN P53, ZINC ION (3 entities in total)
• 機能のキーワード: activator, anti-oncogene, apoptosis, disease mutation, dna-binding, dna-binding protein, li-fraumeni syndrome, nuclear protein, p53 dna-binding domain, phosphorylation, polymorphism, second-site suppressor mutation, superstable mutant, transcription regulation, tumor suppressor, dna binding protein
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24586.14

構造登録者

Joerger, A.C.,Fersht, A.R. (登録日: 2005-01-25, 公開日: 2005-01-26, 最終更新日: 2023-12-13)

• 主引用文献: Joerger, A.C.,Ang, H.C.,Veprintsev, D.B.,Blair, C.M.,Fersht, A.R.; Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations; J.Biol.Chem., 280:16030-, 2005; PubMed: 15703170; DOI: 10.1074/JBC.M500179200

実験手法

X-RAY DIFFRACTION (1.9 Å)