2BFU
X-ray structure of CPMV top component
Summary for 2BFU
| Entry DOI | 10.2210/pdb2bfu/pdb |
| Related | 1BMV 1NY7 |
| Descriptor | COWPEA MOSAIC VIRUS, LARGE (L) SUBUNIT, COWPEA MOSAIC VIRUS, SMALL (S) SUBUNIT (2 entities in total) |
| Functional Keywords | comovirus, virus, viral coat protein, cowpea mosaic virus cpmv, top component, nanotechnology, empty particles, icosahedral virus |
| Biological source | COWPEA MOSAIC VIRUS More |
| Total number of polymer chains | 2 |
| Total formula weight | 61820.00 |
| Authors | Ochoa, W.F.,Chatterji, A.,Lin, T.,Johnson, J.E. (deposition date: 2004-12-13, release date: 2005-01-12, Last modification date: 2024-10-16) |
| Primary citation | Ochoa, W.F.,Chatterji, A.,Lin, T.,Johnson, J.E. Generation and Structural Analysis of Reactive Empty Particles Derived from an Icosahedral Virus. Chem.Biol., 13:771-, 2006 Cited by PubMed Abstract: Chemical and genetic modifications on the surface of viral protein cages confer unique properties to the virus particles with potential nano and biotechnological applications. The enclosed space in the interior of the virus particles further increases its versatility as a nanomaterial. In this paper, we report a simple method to generate a high yield of stable cowpea mosaic virus (CPMV) empty capsids from their native nucleoprotein counterparts by removing the encapsidated viral genome without compromising the integrity of the protein coat. Biochemical and structural comparison of artificially generated empty particles did not reveal any distinguishable differences from CPMV particles containing viral RNA. Preliminary results on the use of artificially produced empty CPMV capsids as a carrier capsule are described. PubMed: 16873025DOI: 10.1016/J.CHEMBIOL.2006.05.014 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (4 Å) |
Structure validation
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