2BFM

Leishmania major pteridine reductase 1 in complex with NADP and trimethoprim

2BFM の概要

• エントリーDOI: 10.2210/pdb2bfm/pdb
• 関連するPDBエントリー: 1E7W 1E92 1W0C 2BF7 2BFA 2BFO 2BFP
• 分子名称: PTERIDINE REDUCTASE 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETHOPRIM, ... (4 entities in total)
• 機能のキーワード: pteridine reductase, trypanosomatids, drug resistance, pterin salvage, short-chain dehydrogenase/reductase, methotrexate resistance, nadp, oxidoreductase
• 由来する生物種: LEISHMANIA MAJOR
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 125324.64

構造登録者

Schuettelkopf, A.W.,Hunter, W.N. (登録日: 2004-12-09, 公開日: 2005-08-31, 最終更新日: 2023-12-13)

• 主引用文献: Schuettelkopf, A.W.,Hardy, L.W.,Beverley, S.M.,Hunter, W.N.; Structures of Leishmania Major Pteridine Reductase Complexes Reveal the Active Site Features Important for Ligand Binding and to Guide Inhibitor Design; J.Mol.Biol., 352:105-, 2005; PubMed: 16055151; DOI: 10.1016/J.JMB.2005.06.076

実験手法

X-RAY DIFFRACTION (2.6 Å)