2BEL

Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone

Summary for 2BEL

• Entry DOI: 10.2210/pdb2bel/pdb
• Related: 1XU7 1XU9
• Descriptor: CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CARBENOXOLONE, ... (5 entities in total)
• Functional Keywords: oxidoreductase, glucocorticoid activation, drug target, inhibitor, short-chain dehydrogenase/reductase, hormone metabolism, microsome, nadp, steroid metabolism
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 4
• Total formula weight: 129822.31

Authors

Kavanagh, K.,Wu, X.,Svensson, S.,Elleby, B.,von Delft, F.,Debreczeni, J.E.,Sharma, S.,Bray, J.,Edwards, A.,Arrowsmith, C.,Sundstrom, M.,Abrahmsen, L.,Oppermann, U. (deposition date: 2004-11-25, release date: 2004-12-06, Last modification date: 2024-05-01)

• Primary citation: Wu, X.,Kavanagh, K.,Svensson, S.,Elleby, B.,Hult, M.,von Delft, F.,Marsden, B.,Jornvall, H.,Abrahmsen, L.,Oppermann, U.; The High Resolution Structures of Human, Murine and Guinea Pig 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Reveal Critical Differences in Active Site Architecture; To be Published,

Experimental method

X-RAY DIFFRACTION (2.11 Å)