2BEL

Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone

2BEL の概要

• エントリーDOI: 10.2210/pdb2bel/pdb
• 関連するPDBエントリー: 1XU7 1XU9
• 分子名称: CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CARBENOXOLONE, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, glucocorticoid activation, drug target, inhibitor, short-chain dehydrogenase/reductase, hormone metabolism, microsome, nadp, steroid metabolism
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 129822.31

構造登録者

Kavanagh, K.,Wu, X.,Svensson, S.,Elleby, B.,von Delft, F.,Debreczeni, J.E.,Sharma, S.,Bray, J.,Edwards, A.,Arrowsmith, C.,Sundstrom, M.,Abrahmsen, L.,Oppermann, U. (登録日: 2004-11-25, 公開日: 2004-12-06, 最終更新日: 2018-01-24)

• 主引用文献: Wu, X.,Kavanagh, K.,Svensson, S.,Elleby, B.,Hult, M.,von Delft, F.,Marsden, B.,Jornvall, H.,Abrahmsen, L.,Oppermann, U.; The High Resolution Structures of Human, Murine and Guinea Pig 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Reveal Critical Differences in Active Site Architecture; To be Published,

実験手法

X-RAY DIFFRACTION (2.11 Å)