2BEE

Complex Between Paromomycin derivative JS4 and the 16S-Rrna A Site

2BEE の概要

• エントリーDOI: 10.2210/pdb2bee/pdb
• 関連するPDBエントリー: 1J7T 2BE0 2ESI 2ESJ
• 分子名称: 5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', (2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3R,4R,5S)-4-(2-(3-AMINOPROPYLAMINO)ETHOXY)-5-((1R,2R,3S,5R,6S)-3,5-DIAM INO-2-((2S,3R,4R,5S,6R)-3-AMINO-4,5-DIHYDROXY-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLOXY)-2-( HYDROXYMETHYL)-TETRAHYDROFURAN-3-YLOXY)-TETRAHYDRO-2H-PYRAN-3,4-DIOL (3 entities in total)
• 機能のキーワード: rna-aminoglycoside interactions, a site, uou pairs, aa bulges, rna-antibiotic complex, rna/antibiotic
• 由来する生物種: Streptomyces rimosus subsp. paromomycinus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 15528.10

構造登録者

Francois, B.,Westhof, E. (登録日: 2005-10-24, 公開日: 2005-12-20, 最終更新日: 2024-03-13)

• 主引用文献: Francois, B.,Szychowski, J.,Adhikari, S.S.,Pachamuthu, K.,Swayze, E.E.,Griffey, R.H.,Migawa, M.T.,Westhof, E.,Hanessian, S.; Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site; ANGEW.CHEM.INT.ED.ENGL., 43:6735-6738, 2004; PubMed: 15593140; DOI: 10.1002/anie.200462092

実験手法

X-RAY DIFFRACTION (2.6 Å)