2BED
Structure of FPT bound to inhibitor SCH207736
Summary for 2BED
| Entry DOI | 10.2210/pdb2bed/pdb |
| Descriptor | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (6 entities in total) |
| Functional Keywords | fpt, ptase, farnesyl, drug design, transferase |
| Biological source | Rattus norvegicus (Norway rat) More |
| Total number of polymer chains | 2 |
| Total formula weight | 83491.41 |
| Authors | Strickland, C. (deposition date: 2005-10-24, release date: 2006-08-08, Last modification date: 2024-02-14) |
| Primary citation | Njoroge, F.G.,Vibulbhan, B.,Pinto, P.,Strickland, C.,Bishop, W.R.,Nomeir, A.,Girijavallabhan, V. Enhanced FTase activity achieved via piperazine interaction with catalytic zinc. Bioorg.Med.Chem.Lett., 16:984-988, 2006 Cited by PubMed: 16298128DOI: 10.1016/j.bmcl.2005.10.090 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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