2BED

Structure of FPT bound to inhibitor SCH207736

2BED の概要

• エントリーDOI: 10.2210/pdb2bed/pdb
• 分子名称: Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ... (6 entities in total)
• 機能のキーワード: fpt, ptase, farnesyl, drug design, transferase
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83491.41

構造登録者

Strickland, C. (登録日: 2005-10-24, 公開日: 2006-08-08, 最終更新日: 2024-02-14)

• 主引用文献: Njoroge, F.G.,Vibulbhan, B.,Pinto, P.,Strickland, C.,Bishop, W.R.,Nomeir, A.,Girijavallabhan, V.; Enhanced FTase activity achieved via piperazine interaction with catalytic zinc.; Bioorg.Med.Chem.Lett., 16:984-988, 2006; PubMed: 16298128; DOI: 10.1016/j.bmcl.2005.10.090

実験手法

X-RAY DIFFRACTION (2.7 Å)