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2BE0

Complex Between Paromomycin Derivative JS5-39 and the 16S-Rrna A-Site.

Summary for 2BE0
Entry DOI10.2210/pdb2be0/pdb
Related1J7T 2BEE 2ESI 2ESJ
Descriptor5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', (2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3R,4R,5S)-5-((1R,2R,3S,5R,6S)-3,5-DIAMINO-2-((2S,3R,4R,5S,6R)-3-AMINO-4 ,5-DIHYDROXY-6-(HYDROXYMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-6-HYDROXYCYCLOHEXYLOXY)-2-(HYDROXYMETHYL)-4-(2-((R)-PIPERIDI N-3-YLMETHYLAMINO)ETHOXY)-TETRAHYDROFURAN-3-YLOXY)-TETRAHYDRO-2H-PYRAN-3,4-DIOL (3 entities in total)
Functional Keywordsrna-aminoglycoside interactions, a site, uou pairs, aa bulges, rna-antibiotic complex, rna/antibiotic
Biological sourceStreptomyces rimosus subsp. paromomycinus
Total number of polymer chains2
Total formula weight15608.23
Authors
Francois, B.,Westhof, E. (deposition date: 2005-10-21, release date: 2005-12-20, Last modification date: 2024-03-13)
Primary citationFrancois, B.,Szychowski, J.,Adhikari, S.S.,Pachamuthu, K.,Swayze, E.E.,Griffey, R.H.,Migawa, M.T.,Westhof, E.,Hanessian, S.
Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site
ANGEW.CHEM.INT.ED.ENGL., 43:6735-6738, 2004
Cited by
PubMed: 15593140
DOI: 10.1002/anie.200462092
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.63 Å)
Structure validation

217705

数据于2024-03-27公开中

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