2BDJ
Src kinase in complex with inhibitor AP23464
Summary for 2BDJ
Entry DOI | 10.2210/pdb2bdj/pdb |
Related | 2BDF |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, 3-[2-(2-CYCLOPENTYL-6-{[4-(DIMETHYLPHOSPHORYL)PHENYL]AMINO}-9H-PURIN-9-YL)ETHYL]PHENOL (3 entities in total) |
Functional Keywords | src kinase inhibitor, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane: P12931 |
Total number of polymer chains | 1 |
Total formula weight | 32445.29 |
Authors | Dalgarno, D.,Stehle, T.,Schelling, P.,Narula, S.,Sawyer, T. (deposition date: 2005-10-20, release date: 2006-10-24, Last modification date: 2023-08-23) |
Primary citation | Dalgarno, D.,Stehle, T.,Narula, S.,Schelling, P.,van Schravendijk, M.R.,Adams, S.,Andrade, L.,Keats, J.,Ram, M.,Jin, L.,Grossman, T.,MacNeil, I.,Metcalf III, C.,Shakespeare, W.,Wang, Y.,Keenan, T.,Sundaramoorthi, R.,Bohacek, R.,Weigele, M.,Sawyer, T. Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds. Chem.Biol.Drug Des., 67:46-57, 2006 Cited by PubMed: 16492148DOI: 10.1111/j.1747-0285.2005.00316.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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