2BBB

Structure of HIV1 protease and hh1_173_3a complex.

2BBB の概要

• エントリーDOI: 10.2210/pdb2bbb/pdb
• 分子名称: Protease, (3S)-TETRAHYDROFURAN-3-YL (1R)-3-{(2R)-4-[(1S,3S)-3-(2-AMINO-2-OXOETHYL)-2,3-DIHYDRO-1H-INDEN-1-YL]-2-BENZYL-3-OXO-2,3-DIHYDRO-1H-PYRROL-2-YL}-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total)
• 機能のキーワード: protease, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22231.25

構造登録者

Smith III, A.B.,Charnley, A.K.,Kuo, L.C.,Munshi, S. (登録日: 2005-10-17, 公開日: 2005-11-15, 最終更新日: 2023-08-23)

• 主引用文献: Smith III, A.B.,Charnley, A.K.,Harada, H.,Beiger, J.J.,Cantin, L.D.,Kenesky, C.S.,Hirschmann, R.,Munshi, S.,Olsen, D.B.,Stahlhut, M.W.,Schleif, W.A.,Kuo, L.C.; Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2' side chains; Bioorg.Med.Chem.Lett., 16:859-863, 2006; PubMed: 16298527; DOI: 10.1016/j.bmcl.2005.11.011

実験手法

X-RAY DIFFRACTION (1.7 Å)