2B7Z

Structure of HIV-1 protease mutant bound to indinavir

2B7Z の概要

• エントリーDOI: 10.2210/pdb2b7z/pdb
• 関連するPDBエントリー: 2B60
• 分子名称: HIV-1 protease, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE (3 entities in total)
• 機能のキーワード: hiv-1, protease, indinavir, drug resistance, active site mutations, non-active site mutations, viral protein
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22277.20

構造登録者

Clemente, J.C.,Stow, L.R.,Janka, L.K.,Jeung, J.A.,Desai, K.A.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Goodenow, M.M.,Dunn, B.M. (登録日: 2005-10-05, 公開日: 2006-11-14, 最終更新日: 2024-02-14)

• 主引用文献: Clemente, J.C.,Stow, L.R.,Janka, L.K.,Jeung, J.A.,Desai, K.A.,Govindasamy, L.,Agbandje-McKenna, M.,McKenna, R.,Goodenow, M.M.,Dunn, B.M.; In vivo, kinetic, and structural analysis of the development of ritonavir resistance; To be Published,

実験手法

X-RAY DIFFRACTION (2.2 Å)