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2B7M

Crystal Structure of the S. cerevisiae Exocyst Component Exo70p

Summary for 2B7M
Entry DOI10.2210/pdb2b7m/pdb
DescriptorExocyst complex component EXO70 (1 entity in total)
Functional Keywordsexocyst, exocytosis, endocytosis-exocytosis complex, endocytosis/exocytosis
Biological sourceSaccharomyces cerevisiae (baker's yeast)
Cellular locationBud: P19658
Total number of polymer chains4
Total formula weight262149.62
Authors
Hamburger, Z.A.,Hamburger, A.E.,West, A.P.,Weis, W.I. (deposition date: 2005-10-04, release date: 2005-11-15, Last modification date: 2011-07-13)
Primary citationHamburger, Z.A.,Hamburger, A.E.,West, A.P.,Weis, W.I.
Crystal Structure of the S.cerevisiae Exocyst Component Exo70p
J.Mol.Biol., 356:9-21, 2006
Cited by
PubMed Abstract: The exocyst is an evolutionarily conserved multiprotein complex required for the targeting and docking of post-Golgi vesicles to the plasma membrane. Through its interactions with a variety of proteins, including small GTPases, the exocyst is thought to integrate signals from the cell and signal that vesicles arriving at the plasma membrane are ready for fusion. Here we describe the three-dimensional crystal structure of one of the components of the exocyst, Exo70p, from Saccharomyces cerevisiae at 3.5A resolution. Exo70p binds the small GTPase Rho3p in a GTP-dependent manner with an equilibrium dissociation constant of approximately 70 microM. Exo70p is an extended rod approximately 155 angstroms in length composed principally of alpha helices, and is a novel fold. The structure provides a first view of the Exo70 protein family and provides a framework to study the molecular function of this exocyst component.
PubMed: 16359701
DOI: 10.1016/j.jmb.2005.09.099
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.5 Å)
Structure validation

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数据于2024-10-30公开中

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