2AZM

Crystal structure of the MDC1 brct repeat in complex with the histone tail of gamma-H2AX

2AZM の概要

• エントリーDOI: 10.2210/pdb2azm/pdb
• 分子名称: Mediator of DNA damage checkpoint protein 1, GAMMA-H2AX HISTONE (3 entities in total)
• 機能のキーワード: brct repeat, protein-phosphopeptide complex, dna damage, cell cycle
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: Q14676
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 48240.40

構造登録者

Clapperton, J.A.,Stucki, M.,Mohammad, D.,Yaffe, M.B.,Jackson, S.P.,Smerdon, S.J. (登録日: 2005-09-12, 公開日: 2006-01-31, 最終更新日: 2011-07-13)

• 主引用文献: Stucki, M.,Clapperton, J.A.,Mohammad, D.,Yaffe, M.B.,Smerdon, S.J.,Jackson, S.P.; MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks; Cell(Cambridge,Mass.), 123:1213-1226, 2005; PubMed: 16377563; DOI: 10.1016/j.cell.2005.09.038

実験手法

X-RAY DIFFRACTION (2.41 Å)