2AXN

Crystal structure of the human inducible form 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

2AXN の概要

• エントリーDOI: 10.2210/pdb2axn/pdb
• 分子名称: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (6PF-2-K/Fru- 2,6-P2ASE brain/placenta-type isozyme) (iPFK-2) [Includes: 6- phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)], 6-O-phosphono-beta-D-fructofuranose, {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID, ... (5 entities in total)
• 機能のキーワード: bifunctional enzyme, edta complex, transferase, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 60673.72

構造登録者

Kim, S.G.,Manes, N.P.,El-Maghrabi, M.R.,Lee, Y.H. (登録日: 2005-09-05, 公開日: 2005-12-06, 最終更新日: 2023-08-23)

• 主引用文献: Kim, S.G.,Manes, N.P.,El-Maghrabi, M.R.,Lee, Y.H.; Crystal structure of the hypoxia-inducible form of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): a possible new target for cancer therapy.; J.Biol.Chem., 281:2939-2944, 2006; PubMed: 16316985; DOI: 10.1074/jbc.M511019200

実験手法

X-RAY DIFFRACTION (2.1 Å)