2AVS
kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, and G73S
Summary for 2AVS
Entry DOI | 10.2210/pdb2avs/pdb |
Descriptor | Pol polyprotein, PHOSPHATE ION, SULFATE ION, ... (7 entities in total) |
Functional Keywords | drug resistance, hiv-1 protease, indinavir, substrate analog, non-active site mutants., hydrolase |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587 |
Total number of polymer chains | 2 |
Total formula weight | 22671.43 |
Authors | Liu, F.,Boross, P.I.,Wang, Y.F.,Tozser, J.,Louis, J.M.,Harrison, R.W.,Weber, I.T. (deposition date: 2005-08-30, release date: 2006-01-24, Last modification date: 2023-08-23) |
Primary citation | Liu, F.,Boross, P.I.,Wang, Y.F.,Tozser, J.,Louis, J.M.,Harrison, R.W.,Weber, I.T. Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. J.Mol.Biol., 354:789-800, 2005 Cited by PubMed: 16277992DOI: 10.1016/j.jmb.2005.09.095 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.1 Å) |
Structure validation
Download full validation report