2AUH
Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine kinase
Summary for 2AUH
Entry DOI | 10.2210/pdb2auh/pdb |
Descriptor | Insulin receptor, Growth factor receptor-bound protein 14, CALCIUM ION (3 entities in total) |
Functional Keywords | tyrosine kinase, bps region, transferase-signaling protein complex, transferase/signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P06213 Cytoplasm: Q14449 |
Total number of polymer chains | 2 |
Total formula weight | 41439.91 |
Authors | Depetris, R.S.,Hu, J.,Gimpelevich, I.,Holt, L.J.,Daly, R.J.,Hubbard, S.R. (deposition date: 2005-08-27, release date: 2005-11-01, Last modification date: 2023-11-15) |
Primary citation | Depetris, R.S.,Hu, J.,Gimpelevich, I.,Holt, L.J.,Daly, R.J.,Hubbard, S.R. Structural basis for inhibition of the insulin receptor by the adaptor protein grb14. Mol.Cell, 20:325-333, 2005 Cited by PubMed: 16246733DOI: 10.1016/j.molcel.2005.09.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
Download full validation report