2AS0

Crystal Structure of PH1915 (APC 5817): A Hypothetical RNA Methyltransferase

2AS0 の概要

• エントリーDOI: 10.2210/pdb2as0/pdb
• 分子名称: hypothetical protein PH1915 (2 entities in total)
• 機能のキーワード: rna methyltransferase, structural genomics, psi, protein structure initiative, midwest center for structural genomics, mcsg, transferase
• 由来する生物種: Pyrococcus horikoshii
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90664.87

構造登録者

Sun, W.,Xu, X.,Pavlova, M.,Edwards, A.M.,Joachimiak, A.,Savchenko, A.,Christendat, D.,Midwest Center for Structural Genomics (MCSG) (登録日: 2005-08-22, 公開日: 2005-09-20, 最終更新日: 2024-11-06)

主引用文献

Sun, W.,Xu, X.,Pavlova, M.,Edwards, A.M.,Joachimiak, A.,Savchenko, A.,Christendat, D.
The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii.
Protein Sci., 14:3121-3128, 2005

PubMed Abstract: The S-adenosyl-L-methionine (SAM)-dependent methyltransferases represent a diverse and biologically important class of enzymes. These enzymes utilize the ubiquitous methyl donor SAM as a cofactor to methylate proteins, small molecules, lipids, and nucleic acids. Here we present the crystal structure of PH1915 from Pyrococcus horikoshii OT3, a predicted SAM-dependent methyltransferase. This protein belongs to the Cluster of Orthologous Group 1092, and the presented crystal structure is the first representative structure of this protein family. Based on sequence and 3D structure analysis, we have made valuable functional insights that will facilitate further studies for characterizing this group of proteins. Specifically, we propose that PH1915 and its orthologs are rRNA- or tRNA-specific methyltransferases.

PubMed: 16260766
DOI: 10.1110/ps.051821805

実験手法

X-RAY DIFFRACTION (1.8 Å)